5-Fluorosalicylic acid
CAS Number 345-16-4
Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers, Non-Heterocyclic Building Blocks
A fluorinated salicylic acid building block
A metal chelating agent and building block for fluorescence immunoassay, pH sensors and APIs
Specifications | MSDS | Literature and Reviews
5-Fluorosalicylic acid (CAS number 345-16-4), also known as 5-fluoro-2-hydroxybenzoic acid, has a fluorine substituent at 5-position and a hydroxyl group at 2-position. As an ortho-hydroxybenzoic acid, 5-fluorosalicylic acid is a good chelating agent. It forms highly fluorescent ternary complexes with terbium (Tb3+) that are employed in immunoassay. 5-Fluorosalicylic acid binds to copper (Cu2+) generating three isomers. Each isomer is formed predominantly depending on the pH value. Thus, 5-fluorosalicylic acid-copper complexes can be used for pH sensors. A flexible trifurcate titanium with 5-fluorosalicylic acid metalloligand can encapsulate silver nanoclusters in tetrahedral geometry. The metalloligand induces spatial growth and stability to the nanoclusters in non-linear optical and photoluminescent applications.
5-Fluorosalicylic acid is also used as a building block for active pharmaceutical ingredients (APIs) such as fluorinated deferasirox for chronic iron overload.
Multiple functional groups
For facile synthesis
Fluorinated salicylic acid building block
For drug discovery, metal complexes and dyes
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
| CAS Number | 345-16-4 |
| Chemical Formula | C7H5FO3 |
| Full Name | 5-Fluorosalicylic acid |
| Molecular Weight | 156.11 g/mol |
| Synonyms | 5-Fluoro-2-hydroxybenzoic acid, 2-Hydroxy-5-fluorobenzoic acid |
| Classification / Family | Fluorinated building block, Ligands, Fluorescence immunoassay, APIs, Sensors |
Chemical Structure
Product Details
| Purity | 98% |
| Melting Point | Tm = 177 – 179 °C |
| Appearance | Pale beige powder |
MSDS Documentation
5-Fluorosalicylic acid MSDS Sheet
Literature and Reviews
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Complexation of 5-fluorosalicylic acid with copper(II): a pH-potentiometric, UV–vis spectroscopic, and electron spin resonance study by the two-dimensional simulation of spectra, T. Szabó-Plánka et al., J. Inorg. Biochem., 102, 101–109 (2008); DOI: 10.1016/j.jinorgbio.2007.07.019.
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Enzymatically amplified time-resolved fluorescence immunoassay with terbium chelates, T. Christopoulos et al., Anal. Chem., 64(4), 342–346(1992); DOI: 10.1021/ac00028a004.
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Tetrahedral geometry induction of stable Ag-Ti nanoclusters by flexible trifurcate TiL3 metalloligand, M.-Y. Gao et al., J. Am. Chem. Soc., 142(29), 12784–12790(2020); DOI: 10.1021/jacs.0c05199.