3-Fluoro-p-anisidine

CAS Number 366-99-4

Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers

A fluorinated p-anisidine building block

Used as a precursor for heterocycles in application of APIs

Specifications | MSDS | Literature and Reviews

3-Fluoro-p-anisidine (CAS number 366-99-4), also referred to as 3-fluoro-4-methoxyaniline, is an aniline with a fluoride and a methoxy substituted at 3- and 4-positions. 3-Fluoro-p-anisidine is commonly used as a precursor for synthesising quinoline derivatives through Combes quinoline synthesis with 1,3-diketones. The as synthesised quinoline derivatives are employed as active pharmaceutical ingredients and dyes. 3-Fluoro-p-anisidine is readily attached to molecular scaffolds through nucleophilic substitution.

The primary amine in 3-fluoro-p-anisidine can be used to prepare azides for copper-catalysed azide-alkyne cycloaddition (click reaction).

Multiple functional groups

For facile synthesis

Fluorinated aniline building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	366-99-4
Chemical Formula	C₇H₈FNO
Full Name	3-Fluoro-4-methoxyaniline
Molecular Weight	141.15 g/mol
Synonyms	4-Amino-2-fluoroanisole, 3-Fluoro-4-methoxyaniline, 4-Amino-2-fluoro-1-methoxybenzene
Classification / Family	Fluorinated building blocks, Aniline building blocks, APIs, Heterocycles

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 81 °C – 83 °C
Appearance	Brown powder

MSDS Documentation

3-Fluoro-p-anisidine MSDS Sheet

Literature and Reviews

7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases, D. Boschelli et al., J. Med. Chem., 47(7), 1599–1601(2004); DOI: 10.1021/jm0499458.
CuI-mediated synthesis of 1-aryl-5,6,7-trimethoxybenzimidazoles as potent antitubulin agents, C.-M. Peng et al., RSC Adv., 13, 13169(2023); DOI: 10.1039/d3ra01927f.
Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells, W. Zhao et al., Sci. Rep., 5, 17175(2015); DOI: 10.1038/srep17175.

Synthesis and dual PPARa/d agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516, C. Ciocoiu et al., Eur. J. Med. Chem., 45, 3047–3055(2010); DOI: 10.1016/j.ejmech.2010.03.035.
Synthesis, biodistribution and micro-PET imaging of radiolabelled antimitotic agent T138067 analogues, X. Fei et al., Bio. Med. Chem. Lett., 14, 1247–1251(2004); DOI: 10.1016/j.bmcl.2003.12.061.