2,4,5-Trifluorophenylacetic acid
CAS Number 209995-38-0
Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers, Non-Heterocyclic Building Blocks
A fluorinated phenylacetic acid
Used as an additive for perovskite solar cells, as well as a synthesis intermediate for active pharmaceutical ingredients (APIs)
Specifications | MSDS | Literature and Reviews
2,4,5-Trifluorophenylacetic acid (CAS number 209995-38-0) is a phenylacetic acid with three fluorine atoms substituted on the benzene ring. 2,4,5-Trifluorophenylacetic acid is applied as a bifunctional additive for stable and efficient perovskite solar cell. The carboxylic acid group within 2,4,5-trifluorophenylacetic acid interacts with the Pb cluster and passivates the deep-energy-level defects of the perovskites. This leads to an enhancement of power conversion efficiency (PCE) from 22.95% to 24.56% (device structure: FTO/TiO2/2,4,5-Trifluorophenylacetic acid:FAI:PbI/Spiro-OMeTAD:LiTFSI:tBP/Au). Additionally, the hydrophobicity of the trifluorobenzene moiety improves the stability of the solar cell, maintaining 93.6% of its initial efficiency when stored in air for 3912 hours.
2,4,5-Trifluorophenylacetic acid is also a precursor for the synthesis of sitagliptin through a four-step reaction with an overall yield of 65%. Sitagliptin is an anti-diabetic medication for the treatment of type-2 diabetes.
Multiple functional groups
For facile synthesis
Fluorinated phenylacetic acid building block
For drug discovery, medicinal chemistry, and perovskite solar cells
Low Cost
Competitively priced, high quality product
High purity
>98% High purity
General Information
| CAS Number | 209995-38-0 |
| Chemical Formula | C8H5F3O2 |
| Full Name | (2,4,5-Trifluorophenyl)acetic acid |
| Molecular Weight | 190.12 g/mol |
| Synonyms | 2,4,5-Trifluorobenzeneacetic acid, 2-(2,4,5-Trifluorophenyl)acetic acid, TFPB |
| Classification / Family | Fluorinated building blocks, Phenylacetic acid building blocks, Perovskite solar cell additives, Solid additive, APIs |
Chemical Structure
Product Details
| Purity | 98% |
| Melting Point | Tm = 121 °C – 125 °C |
| Appearance | White powder |
MSDS Documentation
2,4,5-Trifluorophenylacetic acid MSDS Sheet
Literature and Reviews
- Bifunctional trifluorophenylacetic acid additive for stable and highly efficient flexible perovskite solar cell, Y. Cao et al., InfoMat., 5, e12423 (2023); DOI: 10.1002/inf2.12423.
- Mechanistic evidence for an α-oxoketene pathway in the formation of β-ketoamides/esters via Meldrum's acid adducts, F. Xu et al., J. Am. Chem. Soc., 126, 13002–13009 (2004); DOI: 10.1021/ja046488b.
- Highly efficient asymmetric synthesis of sitagliptin, K. Hansen et al., J. Am. Chem. Soc., 131, 8789–8804 (2009); DOI: 10.1021/ja902462q.