2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

CAS Number 82671-02-1

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Monomers

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile MSDS

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile CAS 82671-02-1

A halogenated pyridinecarbonitrile

Used as a synthetic precursor for APIs

Overview
Related Products

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile (CAS number 82671-02-1), also referred to as 2,6-dichloro-3-cyano-5-fluoropyridine, is derived from pyridine with two chlorides, a fluoride and a nitrile substituents. The most recognised reaction using 2,6-dichloro-5-fluoro-3-pyridinecarbonitrile is the synthesis of Gemifloxacin, an oral broad-spectrum antibiotic. Other than Gemifloxacin, 2,6-dichloro-5-fluoro-3-pyridinecarbonitrile is also a molecular scaffold for 1,8-naphthyridine derivatives including Enoxacin, Trovafloxacin and Tosufloxacin. 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile enables facile synthesis of a wide range of fluoroquinolone derivatives with different building blocks for reducing the side effects of medication and expanding the medical applications.

Multiple functional groups

For facile synthesis

Fluorinated nicotinonitrile building block

For organic synthesis, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	82671-02-1
Chemical Formula	C₆HCl₂FN₂
Full Name	2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile
Molecular Weight	190.99 g/mol
Synonyms	2,6-Dichloro-3-cyano-5-fluoropyridine, 2,6-Dichloro-5-fluoro-3-nicotinonitrile, 2,6-Dichloro-5-fluoronicotinonitrile
Classification / Family	Fluorinated building blocks, Heterocyclic building blocks, APIs, Antibiotics, Bicyclic compounds

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 89 °C – 91 °C
Appearance	White powder

MSDS Documentation

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile MSDS Sheet

Literature and Reviews

Novel fluoroquinolone antibacterial agents containing oxime-substituted (aminomethyl)pyrrolidines: synthesis and antibacterial activity of 7-(4-(aminomethyl)-3-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl-6- fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid (LB20304), C. Hong et al., J. Med. Chem., 40(22), 3584–3593(1997); DOI: 10.1021/jm970202e.
Synthesis and in vitro antibacterial activity of Gemifloxacin derivatives containing a substituted benzyloxime moiety, L. Feng et al., Eur. J. Med. Chem., 55, 125–136(2012); DOI: 10.1016/j.ejmech.2012.07.010.
Synthesis, spectroscopic, and biological studies of mixed ligand complexes of Gemifloxacin and glycine with Zn(II), Sn(II), and Ce(III), Molecules, 23, 1182(2018); DOI: 10.3390/molecules23051182.
Synthesis and in vitro antitumor activity of novel naphthyridinone derivatives, X.-D. Jia et al., Chin. Chem. Lett., 28(2), 235–239(2017); DOI: 10.1016/j.cclet.2016.07.024.

Related Products

We stock a wide range of monomer available to purchase online. Please contact us if you cannot find what you are looking for.

Potassium nonafluoro-1-butanesulfonate

From £50

2-Fluorobiphenyl

From £40

Pentafluorobenzoic acid

From £30

2,4,5-Trifluorophenylacetic acid

From £40

4-Fluoro-1,2-phenylenediamine

From £35

5-Fluorobenzoxazole-2-thiol

From £45

5-Bromo-3-fluoropyridine-2-carboxylic acid

From £55

7-Fluoro-4-hydroxycoumarin

From £50

2-Amino-5-chloro-3-fluoropyridine

From £40

5-Fluoro-2-methylbenzoic acid

From £45

5-Bromo-4-fluoro-2-methylaniline

From £60

3′-Bromo-4′-fluoroacetophenone

From £35

3-Fluoro-5-(trifluoromethyl)benzoic acid

From £30

5-Chloro-2-fluorobenzonitrile

From £40

2-Fluoro-6-methylbenzoic acid

From £33

4′-Fluoro-3′-nitroacetophenone

From £35

4-Fluoro-3-methylbenzoic acid

From £50

1,3,5-Tris(3-fluoro-4-formylphenyl)benzene

£80
From £80

5-Chloro-2-fluorobenzoic acid

From £50

2-Fluoro-5-methylbenzoic acid

From £50

trans-3,4-Difluorocinnamic acid

From £50

4-Fluoro-2-iodobenzoic acid

From £35

3-Fluoro-4-iodopyridine

From £50

2-Chloro-5-fluoronitrobenzene

From £45

4-Bromo-3-fluorobenzonitrile

From £50

3-Bromo-5-fluorophenol

From £33

4-Bromo-3-fluoroiodobenzene

From £35

5-Difluoromethoxy-2-mercaptobenzimidazole

From £65

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline

From £95

4-Bromo-6-fluoroquinoline

From £95

4-Amino-2-(trifluoromethyl)pyridine

From £50

1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde

From £70

Methyl 6-fluoropyridine-2-carboxylate

From £85

4-Hydroxy-2-(trifluoromethyl)benzoic acid

From £65

5-Bromo-2-fluoropyrimidine

From £60

3-Chloro-5-fluoroaniline

From £65

6-Fluoropyridine-2-carbonitrile

From £80

4-Fluoro-4′-methoxybenzophenone

From £90

2,4,6-Trifluorophenylacetic acid

From £90

2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid

From £80

2-Fluoropyridine-3-carbonitrile

From £90

2-Bromo-5-fluorobenzonitrile

From £60

1-Bromo-2-chloro-4-fluorobenzene

From £70

2-Fluoro-4-(trifluoromethyl)benzoic acid

From £100

3-Fluoro-4-methoxybenzoic acid

From £90

4-Methoxy-3-(trifluoromethyl)aniline

From £90

4-Fluoro-2-methylbenzonitrile

From £90

3-Fluoro-4-(trifluoromethyl)benzoic acid

From £90

3,5-Difluoropyridine-2-carbonitrile

From £90

5-Cyano-2-fluoropyridine

From £90

2,6-Difluorocinnamic aldehyde

From £90

2-Fluoro-4-hydroxybenzoic acid

From £90

3-Chloro-2-fluorobenzoic acid

From £75

2-Fluoro-3-methoxybenzaldehyde

From £137

3-Fluorobenzoic hydrazide

From £100

2-Amino-5-fluorobenzonitrile

From £80

4-Fluoro-2-methylphenol

From £60

2,4,5-Trifluorobenzonitrile

From £80

4-Chloro-3-fluoroaniline

From £50

2-Fluoro-4-nitroaniline

From £70

3-Fluoro-2-methylbenzoic acid

From £90

2-Amino-6-fluorobenzonitrile

From £90

3-Fluoro-p-anisidine

From £90

3′-Fluoro-4′-methoxyacetophenone

Price £90

2-Bromo-4-fluorobenzonitrile

From £80

3-Fluoro-2-pyridinecarbonitrile

From £70

2-Amino-3-fluoropyridine

From £80

3-Fluoro-4-hydroxybenzaldehyde

From £80

α,α-Difluorophenylacetic acid

From £70

3,3-Difluoropiperidine hydrochloride

From £60

2,2-Difluorocyclopropanecarboxylic acid

From £90

4-Fluoro-β-nitrostyrene

From £90

2-Fluoro-4-(trifluoromethyl)aniline

From £90

N-Boc-4,4-difluoro-L-proline

From £70

3,4,5-Trifluorobenzoic acid

From £90

2-Bromo-3′-fluoroacetophenone

From £116

4-Fluororesorcinol

From £70

3,4,5-Trifluoroaniline

From £55

4-Fluorobenzenesulfonamide

From £65

2-Fluoro-5-nitrobenzoic acid

From £65

1-Bis(4-fluorophenyl)methyl piperazine

From £80

3,5-Difluorobenzonitrile

From £65

6-Fluoronicotinic acid

From £76

2-Bromo-4-fluoropyridine

From £125

3-Fluoro-2-hydroxybenzaldehyde

From £110

2-Chloro-5-fluoropyrimidine

From £100

2-Bromo-6-fluorobenzaldehyde

From £100

2-Fluoro-5-nitrobenzonitrile

From £72

Bis(4-fluorophenyl)methanol

From £105

N-Boc-trans-4-fluoro-L-proline

From £76

(S)-(+)-3-Fluoropyrrolidine hydrochloride

From £80

Methyl pentafluorobenzoate

From £76

5-Fluorosalicylic acid

From £110

(R)-(−)-3-Fluoropyrrolidine hydrochloride

From £72

4-Bromo-2,6-difluoroaniline

From £76

2-Fluoroadenine

From £90

3,3-Difluoropyrrolidine hydrochloride

From £110

4-Fluoro-3-nitrobenzoic acid

From £66

2-Amino-4-fluorophenol

From £56

2,4-Difluorobenzonitrile

From £66

2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone

From £100

4,4′-Bis(trifluoromethyl)-2,2′-bipyridine

From £100

5-Bromo-2-fluoropyridine

From £105

1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone

From £90

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

From £80

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

From £115

3-Fluoro-4-morpholinoaniline

From £100

Benzyl (3-Fluoro-4-morpholinophenyl)carbamate

From £100

5-Fluoroisatin

From £76

5-Fluorooxindole

From £200

5-(Trifluoromethoxy)isatin

From £115

6-Fluoroindole-2-carboxylic acid

From £105

6-Fluoroindole

From £80

5-Fluoroindole

From £100

7-Fluoroindole

From £170

3-(4-Fluorophenyl)-1-isopropylindole

From £100

4-Fluoroindole

From £100

4-(Trifluoromethyl)-1H-imidazole

From £165

1-[2-(Trifluoromethyl)phenyl]imidazole

From £175

3-(Trifluoromethyl)-2-pyridone

From £100

5-(Trifluoromethyl)-2-pyridone

From £100

2-(Trifluoromethyl)thioxanthen-9-one

Price £95

2-Furoyltrifluoroacetone

From £100

7-(Diethylamino)-4-(trifluoromethyl)coumarin

From £110

7-Hydroxy-4-(trifluoromethyl)coumarin

From £56

2-Fluoro-9H-carbazole

From £135

AB-TFMB

£90
From £90

p-6FDAP

£110
From £110

2,2-Bis(3-(3-aminobenzoylamino)-4-hydroxyphenyl)hexafluoropropane (m-6FDAP)

£130
From £130

2,2'-Bis(trifluoromethyl)-4,4'-diaminodiphenyl ether (6FODA)

£76
From £76

2,2-Bis[4-(4-aminophenoxy)phenyl]hexafluoropropane (4-BDAF)

£76
From £76

1,4-Bis(4-amino-2-trifluoromethylphenoxy)benzene (6FAPB)

£76
From £76

4,4'-(Hexafluoroisopropylidene)diphthalic anhydride (6FDA)

£90
From £90

2,2'-Bis(trifluoromethyl)benzidine (TFMB)

£76
From £76

2,2-Bis(3-amino-4-hydroxyphenyl)hexafluoropropane (6FAP)

£76
From £76

2-(2,4-Difluorophenyl)-5-fluoropyridine

From £105

2-(2,4-Difluorophenyl)-5-methylpyridine

From £130

4-Chloro-7-trifluoromethylquinoline-3-carboxylic acid ethyl ester

From £145

4-Bromo-8-fluoroquinoline

From £135

6-Chloro-8-fluoroquinoline

From £80

8-Fluoro-4-hydroxy-2-methylquinoline

From £95

(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone

From £145

2,4,6-Trifluoronitrobenzene

From £74

Ethyl (4-fluorobenzoyl)acetate

From £110

5-Bromo-3-fluorosalicylaldehyde

From £110

6-Fluoro-4-chromanone

From £120

2-(Difluoromethyl)benzimidazole

From £115

3,3-Difluoroazetidine hydrochloride

Price £170

4-(Trifluoromethyl)-2-pyridone

From £72

4-Fluoro-1H-indazole

From £72

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

From £115

5,5'-Bis(trifluoromethyl)-2,2'-bipyridine

From £210

5,5'-dibromo-3,3'-difluoro-2,2'-bithiophene

From £250

2-Bromo-6-fluoronaphthalene

From £130

FIC

From £220

HDOQx-DBrDF

From £520

MeHDOQx-DBrDF

From £520

2FIC

From £360

BDTT-F-Sn

From £500

DFBTA-2ThBr-HD

From £310

3,3'-Difluoro-5,5'-bis(trimethylstannyl)-2,2'-bithiophene

From £280

2-Ethylhexyl 4,6-dibromo-3-fluorothieno[3,4-b]thiophene-2-carboxylate

From £260

4,7-Dibromo-5,6-difluoro-2,1,3-benzothiadiazole

From £210

PCE11 Monomer

From £480