2-Amino-6-fluorobenzonitrile

A fluorinated benzonitrile building block

Used as a precursor for synthesising bicyclic heterocycles in medicinal chemistry research

Specifications | MSDS | Literature and Reviews

2-Amino-6-fluorobenzonitrile (CAS number 77326-36-4) is a synthesis intermediate bearing multiple functional groups including a fluoride, a nitrile and an amine. The ortho-position of amine and nitrile groups in 2-amino-6-fluorobenzonitrile is ideal for synthesising quinazolines. Quinazoline derivatives are bicyclic heterocycles used for antimalaria and anticancer treatments, such as Gefitinib, Lapatinib, Erlotinib and Afatinib.

2-Amino-6-fluorobenzonitrile is also used to synthesise aminoquinoline derivatives by reacting with ketones. Tacrine derivatives, cholinesterase inhibitors for Alzheimer's disease, can be obtained with such method.

Multiple functional groups

For facile synthesis

Fluorinated benzonitrile/aniline building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

Chemical Structure

Product Details

MSDS Documentation

2-Amino-6-fluorobenzonitrile MSDS Sheet

Literature and Reviews

1. Huprines as a new family of dual acting trypanocidal–antiplasmodial agents, J. Defaux et al., Bioorg. Med. Chem., 19, 1702–1707(2011); DOI: 10.1016/j.bmc.2011.01.028.
2. Fluorine-containing heterocycles: XVIII.* monofluoroderivatives of quinazolines and 1,3-benzothiazin-4-ones, E. Nosova et al., Russ. J. Org. Chem., 45, 904–912(2009); DOI: 10.1134/S1070428009060189.
3. Synthesis of 5- and 7-fluoroquinazolin-4(1H)-ones, A. Layeva et al., Russ. Chem. Bull., 56, 1821–1827(2007); DOI: 10.1007/s11172-007-0283-x.