2-Chloro-5-fluoropyrimidine

CAS Number 62802-42-0

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers

2-Chloro-5-fluoropyrimidine CAS 62802-42-0

A fluorinated pyrimidine building block

Applied as a synthesis intermediate for APIs and OLEDs

Specifications | MSDS | Literature and Reviews

5-Fluoro-2-chloropyrimidine (CAS number 62802-42-0) is derived from pyrimidine, an aromatic heterocyclic 6-membered ring with two nitrogen atoms at positions 1 and 3. 5-Fluoro-2-chloropyrimidine also has a fluorine and a chlorine substituents at the para-position, making it useful for synthesizing linear molecules. With two nitrogens in the ring, 5-fluoro-2-chloropyrimidine is π electron deficient which facilitates nucleophilic aromatic substitution. 2-Chloro-5-fluoropyrimidine is often used to synthesize active pharmaceutical ingredients (APIs), such as antibiotics.

5-Fluoro-2-chloropyrimidine is also used to synthesize ligands for iridium complexes. The iridium complexes show great external quantum efficiency exceeding 29.5%.

Multiple functional groups

For facile synthesis

Fluorinated pyrimidine building block

For drug discovery, organometallic ligands and semiconducting materials

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	62802-42-0
Chemical Formula	C₄H₂ClFN₂
Full Name	2-Chloro-5-fluoropyrimidine
Molecular Weight	132.52 g/mol
Synonyms	5-Fluoro-2-chloropyrimidine
Classification / Family	Fluorinated building block, Heterocyclic building block, APIs, OLEDs

Chemical Structure

Product Details

Purity	98%
Boiling Point	T_b = 172 – 174 °C at 760 mmHg
Relative Density	1.073 g/mL at 25 °C
Appearance	Colourless liquid

MSDS Documentation

2-Chloro-5-fluoropyrimidine MSDS Sheet

Literature and Reviews

Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist, W. Karstens et al., Bioorg. Med. Chem., 84, 117258(2023); DOI: 10.1016/j.bmc.2023.117258.
Novel pyrimidine-piperazine hybrids as potential antimicrobial agents: in-vitro antimicrobial and in-silico studies, S. Rejinthala et al., Results in Chemistry, 5, 100951(2023); DOI: 10.1016/j.rechem.2023.100951 .
Synthesis, evaluation, and mechanism study of new tepotinib derivatives as antiproliferative agents, N.-N. Zhang et al., Molecules, 24, 1173(2019); DOI: 10.3390/molecules24061173.

Green iridium complexes based on pyrimidine derivatives for efficient electroluminescence with EQE near 30%, H.-B. Han et al., Dyes Pigm., 160, 863–871(2019); DOI: 10.1016/j.dyepig.2018.09.017.