2-Fluoro-3-methoxybenzaldehyde

A fluorinated benzaldehyde building block

Utilised as a key precursor for drug discoveries

Specifications | MSDS | Literature and Reviews

2-Fluoro-3-methoxybenzaldehyde (CAS number 103438-88-6) is a benzaldehyde building block, bearing a fluoride and a methoxy at 2- and 3-positions. 2-Fluoro-3-methoxybenzaldehyde finds widespread use as a precursor for active pharmaceutical ingredients (APIs), particularly in the synthesis of benzosuberone derivatives. To construct benzosuberone cores, 2-fluoro-3-methoxybenzaldehyde reacts with (3-carboxypropyl)triphenylphosphonium bromide through a Wittig reaction. The formation of cycloheptanone ring is achieved through a Friedel-Craft acylation using Eaton's reagent (phosphorus pentoxide and methanesulfonic acid).

2-Fluoro-3-methoxybenzaldehyde is also employed in the synthesis of bicyclic heterocycles, including hydroisoquinolines, acrydinone and quinazolines.

Multiple functional groups

For facile synthesis

Fluorinated benzaldehyde building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

Chemical Structure

Product Details

MSDS Documentation

2-Fluoro-3-methoxybenzaldehyde MSDS Sheet

Literature and Reviews

1. Synthesis and pharmacological evaluation of 1-isopropyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel antihypertensive agents, S. Watanuki et al., Chem. Pharm. Bull., 59(8), 1029–1037(2011); DOI: 10.1248/cpb.59.1029.
2. Introducing telescoping process to synthesis of a key intermediate of drug discoveries using design of experiment,K. Nishimura et al., Chem. Pharm. Bull., 64, 1043–1046(2016), DOI: 10.1248/cpb.c16-00187.
3. Synthesis of o-(dimethylamino)aryl ketones acridones, acridinium salts, and 1H-indazoles by the reaction of hydrazone and arynes, A. Dubrovskiy et al., J. Org. Chem., 77(24), 11232–11256(2012); DOI: 10.1021/jo302378w.