2-Fluoro-4-nitroaniline

CAS Number 369-35-7

Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers

A fluorinated aniline building block

Used as a synthesis intermediate for APIs, colour centre-tailored carbon nanotubes and anode materials in Li-ion batteries

Specifications | MSDS | Literature and Reviews

2-Fluoro-4-nitroaniline, (CAS number 369-35-7) is an aniline derivative bearing a fluoride and a nitro group at 2- and 4-positions. 2-Fluoro-4-nitroaniline serves as a versatile molecular scaffold for synthesising active pharmaceutical ingredients (APIs). The amine group conducts nucleophilic substitution and diazotization. The nitro group can be laterally reduced to amine for further reactions. A precursor to the antibiotic candidate TBI-233 is synthesised from 2-fluoro-4-nitroaniline.

2-Fluoro-4-nitroaniline was used to introduce sp³ defects onto semiconducting single-walled carbon nanotubes (SWCNTs) for organic colour centre-tailored carbon nanotubes. A lithium bismaleamate anode material is synthesised from 2-fluoro-4-nitroaniline, demonstrating an electrode capacity of 688.9 mAhg⁻¹.

Multiple functional groups

For facile synthesis

Fluorinated aniline building block

For semiconductors, batteries and colour centre-tailored carbon nanotubes

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	369-35-7
Chemical Formula	C₆H₅FN₂O₂
Full Name	2-Fluoro-4-nitroaniline
Molecular Weight	156.11 g/mol
Synonyms	2-Fluoro-4-nitrobenzenamine
Classification / Family	Fluorinated building blocks, Aniline building blocks, APIs, Li-ion batteries, Anode materials, Colour centre-tailored carbon nanotubes

Chemical Structure

Product Details

Purity	97%
Melting Point	T_m = 122 °C – 130 °C
Appearance	Brown powder

MSDS Documentation

2-Fluoro-4-nitroaniline MSDS Sheet

Literature and Reviews

Synthesis, characteristics, and electrochemical performance of N,N-(p-phenylene)bismaleamate and its fluorosubstitution compound on organic anode materials in lithium-ion batteries, B. Kahsay et al., Electrochim. Acta, 365, 137342(2021); 10.1016/j.electacta.2020.137342.
Practical and scalable two-step process for 6-(2-fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: a key intermediate of the potent antibiotic drug candidate TBI-223, F. Cardoso et al., Org. Process Res. Dev., 27, 1390–1399(2023); DOI: 10.1021/acs.oprd.3c00148.
Discovery of novel conjugates of quinoline and thiazolidinone urea as potential anti-colorectal cancer agent, L. Xiong et al., J. Enzyme Inhib. Med. Chem., 37(1), 2334–2347(2022); DOI: 10.1080/14756366.2022.2117318.

One-pot, large-scale synthesis of organic color center-tailored semiconducting carbon nanotubes, H.-B. Luo et al., ACS Nano, 13, 8417–8424(2019); DOI: 10.1021/acsnano.9b04087.
Lowering the pK_a of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro, C. Martínez et al., Eur. J. Med. Chem., 101, 806–817(2015); DOI: 10.1016/j.ejmech.2015.07.013.