2-Fluoropyridine-3-carbonitrile

CAS Number 3939-13-7

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers

2-Fluoropyridine-3-carbonitrile CAS 3939-13-7

A fluorinated nicotinonitrile building block

Used for the synthesis of bicyclic heterocycles in medicinal chemistry

Specifications | MSDS | Literature and Reviews

2-Fluoropyridine-3-carbonitrile (CAS number 3939-13-7), also named as 2-fluoronicotinonitrile, is a nicotinonitrile building block featuring a fluoride substituent at 2-position. 2-Fluoropyridine-3-carbonitrile commonly serves as a synthesis precursor for active pharmaceutical ingredients (APIs), such as niflumic acid that is used for joint and muscular pain relief. Pyrazopyridine, a bicyclic heterocycle can be synthesised from 2-fluoropyridine-3-carbonitrile. The reaction begins with a nucleophilic aromatic substitution of hydrazine, followed by a pyrazole cyclisation reaction.

Additionally, 2-fluoropyridine-3-carbonitrile can be modified through Minisci reaction for meta- and para-alkylation.

Multiple functional groups

For facile synthesis

Fluorinated hydroxybenzoic acid building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	3939-13-7
Chemical Formula	C₆H₃FN₂
Full Name	2-Fluoronicotinonitrile
Molecular Weight	122.10 g/mol
Synonyms	3-Cyano-2-fluoropyridine
Classification / Family	Fluorinated building blocks, Heterocyclic building blocks, Nicotinonitrile building blocks, APIs

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 28 °C – 33 °C
Appearance	White crystals

MSDS Documentation

2-Fluoropyridine-3-carbonitrile MSDS Sheet

Literature and Reviews

Antiproliferative activity of some newly synthesized substituted pyridine candidates using 4‑(aryl)-6-(naphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile as synthon, A. El-Sayed et al., ACS Omega, 6, 7147–7156(2021); DOI: 10.1021/acsomega.1c00202.
Second-generation CD73 inhibitors based on a 4,6-biaryl-2-thiophyridine scaffold, R. Ghoteimi et al., ChemMedChem, 18, e202200594(2023); DOI: 10.1002/cmdc.202200594.
New reactions of 5-amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile, V. Dotsenko et al., Chem. Proc., 3, 23(2023); DOI: 10.3390/ecsoc-24-08398.

Synthesis, tumor inhibitory and antioxidant activity of new polyfunctionally 2-substituted 5,6,7,8-tetrahydronaphthalene derivatives containing pyridine, thioxopyridine and pyrazolopyridine moieties, N. Hamdy et al., Acta Pol. Pharm., 70(6), 987–1001(2013); ISSN: 0001-6837.
Synthesis and bioactivity of novel amino-pyrazolopyridines, B. Orlikova et al., Eur. J. Med. Chem., 85, 450–457(2014); DOI: 10.1016/j.ejmech.2014.08.008.