3,3-Difluoropiperidine hydrochloride
CAS Number 496807-97-7
Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers
A gem-fluorinated piperidine building block
For improving inhibitory performance of APIs
Specifications | MSDS | Literature and Reviews
3,3-Difluoropiperidine hydrochloride (CAS number 496807-97-7) is a hydrochloride salt of piperidine with two fluoride substituents at 3-position. As a piperidine derivative, 3,3-difluoropiperidine hydrochloride is a ubiquitous building block in pharmaceutical active ingredients (APIs). 3,3-Difluoropiperidine hydrochloride can attach to molecular scaffolds effortlessly through amination. This fluorinated piperidine building block improves the potency of an agonist of apelin receptor with effective concentration EC50 from 162 nM to 6.5 nM. The presence of 3,3-difluoropiperidine has an enhanced selectivity of estrogen positive breast cancer (1600 folds selectivity).
Molecular functionalisation with 3,3-difluoropiperidine hydrochloride is also used as a 19F NMR probe without requiring deuterated solvents or internal standards.
Multiple functional groups
For facile synthesis
Fluorinated piperidine building block
For NMR probe, medicinal chemistry and biochemistry research
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
| CAS Number | 496807-97-7 |
| Chemical Formula | C5H10ClF2N |
| Full Name | 3,3-Difluoropiperidine hydrochloride |
| Molecular Weight | 157.59 g/mol |
| Synonyms | 3 3-Difluoropiperidine HCl, 3,3-Difluoropiperidinium chloride |
| Classification / Family | Fluorinated building block, Heterocyclic building blocks, Piperidine derivatives, APIs |
Chemical Structure
Product Details
| Purity | 98% |
| Melting Point | Tm = 243 °C – 247 °C |
| Appearance | Cream/beige powder |
MSDS Documentation
3,3-Difluoropiperidine hydrochloride MSDS Sheet
Literature and Reviews
- Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor, S. Narayanan et al., Bioorg. Med. Chem., 66, 116789(2022); DOI: 10.1016/j.bmc.2022.116789.
- Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(L)-prolyl}-4-[(30,50-dichloro-isonicotinoyl) amino]-(L)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist, S. Venkatraman et al., Bioorganic Med. Chem. Lett., 19, 5803–5806(2009); DOI: 10.1016/j.bmcl.2009.07.111.
- Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as 19F NMR probes in deuterium-free environments, J. Woods et al., J. Med. Chem.,54(22), 7934–7941(2011); DOI: 10.1021/jm201114t.