3,5-Difluoropyridine-2-carbonitrile

A difluorinated pyridine building block

Serves as a precursor for APIs and TDAF emitters

Specifications | MSDS | Literature and Reviews

3,5-Difluoropyridine-2-carbonitrile (CAS number 298709-29-2), also knowns as 3,5-difluoropicolinonitrile, is a difluorinated cyanopyridine. 3,5-Difluoropyridine-2-carbonitrile is highly electron deficient, thus the fluorine substituents readily undergo nucleophilic aromatic substitution reactions. A thermally activated delayed fluorescence (TADF) emitter, known as 2,4-2(9H-carbazol-9-yl)-1-cyano-pyridine, is prepared using this method, demonstrating maximum current, power and external quantum efficiency values of 27.5 cdA^-1, 25.6 lmW^-1 and 9.1%, respectively, in OLED application.

3,5-Difluoropyridine-2-carbonitrile finds extensive applications as a molecular scaffold in medicinal chemistry such as the synthesis of thiazole analogues for desferrithiocin.

Multiple functional groups

For facile synthesis

Fluorinated picolinonitrile building block

For drug discovery, TADF dyes and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

Chemical Structure

Product Details

MSDS Documentation

3,5-Difluoropyridine-2-carbonitrile MSDS Sheet

Literature and Reviews

1. Carbazole/a-carboline hybrid bipolar compounds as electron acceptors in exciplex or non-exciplex mixed cohosts and exciplex-TADF emitters for high-efficiency OLEDs, Q. Wu et al., J. Mater. Chem. C, 6, 8784(2018); DOI: 10.1039/c8tc02353k.
2. Structure−activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of Haemonchus contortus development, T. Le et al., J. Med. Chem., 62(2), 1036–1053(2019); DOI: 10.1021/acs.jmedchem.8b01789.
3. Desferrithiocin: a search for clinically effective iron chelators, R. Bergeron et al., J. Med. Chem. 57, 9259–9291(2014); DOI: 10.1021/jm500828f.