3-Chloro-5-fluoroaniline

CAS Number 4863-91-6

Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers

A fluorinated aniline building block

For the synthesis of APIs for inflammatory and antiviral treatments

Specifications | MSDS | Literature and Reviews

3-Chloro-5-fluoroaniline (CAS number 4863-91-6) is an aniline derivative bearing chlorine and fluorine substituents at the 3- and 5-positions. 3-Chloro-5-fluoroaniline is extensively used to synthesise active pharmaceutical ingredients (APIs), particularly antiviral compounds targeting the influenza A H1N1 virus. 3-Chloro-5-fluoroaniline can be readily incorporated into molecular scaffolds through reductive amination and nucleophilic substitution. 3-Chloro-5-fluoroaniline is also involved in the synthesis of glucocorticoid receptor agonist for inflammation treatments. The synthesis of the tetrahydroquinoline-based glucocorticoid receptor agonist commences with 3-chloro-5-fluoroaniline reacting with acetone and iodine under Skraup reaction.

The presence of chlorine and fluorine substituents in 3-chloro-5-fluoroaniline enables further functionalisation, such as palladium-catalysed carbon-carbon coupling and nucleophilic aromatic substitution.

Multiple functional groups

For facile synthesis

Fluorinated aniline building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>97% High purity

General Information

CAS Number	4863-91-6
Chemical Formula	C₆H₅ClFN
Full Name	3-Chloro-5-fluoroaniline
Molecular Weight	145.56 g/mol
Synonyms	3-Chloro-5-fluorobenzenamine
Classification / Family	Fluorinated building blocks, Aniline building blocks, APIs

Chemical Structure

Product Details

Purity	97%
Boiling Point	T_b = 226 °C at 760 mmHg
Relative Density	1.45 g/mL
Appearance	Clear liquid

MSDS Documentation

3-Chloro-5-fluoroaniline MSDS Sheet

Literature and Reviews

Aniline-based inhibitors of influenza H1N1 virus acting on hemagglutinin-mediated fusion, R. Leiva et al., J. Med. Chem., 61, 98–118(2018); DOI: 10.1021/acs.jmedchem.7b00908.
Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists, Bioorg. Med. Chem. Lett., 21, 1697–1700(2011); DOI: 10.1016/j.bmcl.2011.01.093.
Species-selective pyrimidineamine inhibitors of Trypanosoma brucei S-adenosylmethionine decarboxylase, O. Volkov et al., J. Med. Chem., 61(3); DOI: 10.1021/acs.jmedchem.7b01654.

4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators, N. Hwang et al., Bioorg. Med. Chem. Lett., 58, 128518(2022); DOI: 10.1016/j.bmcl.2021.128518.