3′-Fluoro-4′-methoxyacetophenone

CAS Number 455-91-4

Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers, Non-Heterocyclic Building Blocks

3′-Fluoro-4′-methoxyacetophenone CAS 455-91-4

A fluorinated acetophenone building block

Used as a synthesis precursor for chalcone derivatives in application of APIs

Specifications | MSDS | Literature and Reviews

3′-Fluoro-4′-methoxyacetophenone (CAS number 455-91-4) is an acetophenone derivative with a fluorine and a methoxy substituents. 3′-Fluoro-4′-methoxyacetophenone is used to prepare chalcone derivatives with benzaldehydes by aldol condensation. Chalcones are α,β-unsaturated ketones employed as active pharmaceutical ingredients (APIs) and fluorescent dyes. Pyrazole derivatives such as celecoxib, an anti-inflammatory drug, are obtained from chalcones reacting with hydrazine derivatives. Chalcone derivatives can be further functionalised to produce epoxides via Juliá–Colonna epoxidation.

3′-Fluoro-4′-methoxyacetophenone is also a key component in Mannich reaction along with formaldehyde and secondary amines, for β-amino-carbonyl compounds, also known as Mannich bases.

Multiple functional groups

For facile synthesis

Fluorinated acetophenone building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	455-91-4
Chemical Formula	C₉H₉FO₂
Full Name	1-(3-fluoro-4-methoxyphenyl)ethan-1-one
Molecular Weight	168.17 g/mol
Synonyms	1-(3-Fluoro-4-methoxyphenyl)-1-ethanone
Classification / Family	Fluorinated building blocks, Acetophenone building blocks, Heterocycles, APIs

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 92 °C – 94 °C
Appearance	Off-white powder

MSDS Documentation

3′-Fluoro-4′-methoxyacetophenone MSDS Sheet

Literature and Reviews

Automated parallel synthesis of chalcone-based screening libraries, D. Powers et al., Tetrahedron, 54, 4085–4096(1998); DOI: 10.1016/S0040-4020(98)00137-9.
(E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one, N. Bailey et al., Molbank, 2021, M1184(2021); DOI: 10.3390/M1184.
Synthesis of 1-aryl-3-phenethylamino-1-propanone hydrochlorides as possible potent cytotoxic agents, E. Mete et al., Molecules, 12(12); 2579–2588(2007); DOI: 10.3390/12122579.

Practical synthesis of chalcone derivatives and their biological activities, J.-C. Jung et al., Molecules, 22, 1872(2017); DOI: 10.3390/molecules22111872.
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diacrylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: preparation of sodium salt for injectable formulation, M. Pal et al., J. Med. Chem., 46, 3975–3984(2003); DOI: 10.1021/jm020563g.