3-Fluoro-4-morpholinoaniline
CAS Number 93246-53-8
Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers
A fluorinated heterocyclic building block
Used as a synthesis intermediate for Schiff bases, carbon nanodots and carbamates in application of APIs, OLEDs and antimicrobials
Specifications | MSDS | Literature and Reviews
3-Fluoro-4-morpholinoaniline (CAS number 93246-53-8) has a fluorinated aniline linked to a morpholine, a heterocycle featuring both amine and ether groups. By having the accessible primary amine, 3-fluoro-4-morpholinoaniline reacts with aldehyde to form Schiff bases. The Schiff base shows a better biofilm inhibition with IC50 (half maximal inhibitory concentration) of 12.97 μM, compared with linezolid (IC50 of 15.93 μM). 3-Fluoro-4-morpholinoaniline can also be modified for sulfonamide and carbamate derivatives that exhibit antimicrobial activity (minimum inhibitory concentration of 6.25-25.0 μg/mL).
4-Morpholinoaniline decorated phenylenediamine carbon nanodots show an improved photoluminescence quantum yield from 28.3% to 41.8%. The fluorinated 4-morpholinoaniline (3-fluoro-4-morpholinoaniline) can be applied to tune the emission wavelength of the carbon nanodots.
Multiple functional groups
For facile synthesis
Fluorinated morpholinoaniline building block
For drug discovery, carbon nanodots, and OLEDs
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
| CAS Number | 93246-53-8 |
| Chemical Formula | C10H13FN2O |
| Full Name | 3-Fluoro-4-morpholinoaniline |
| Molecular Weight | 196.22 g/mol |
| Synonyms | 4-(2-Fluoro-4-aminophenyl)morpholine, 3-Fluoro-4-morpholin-4-yl-phenylamine, 3-Fluoro-4-(4-morpholinyl)-benzenamine |
| Classification / Family | Fluorinated building block, Heterocyclic building block, Schiff base, Carbon nanodots, APIs, OLEDs, Antimicrobials |
Chemical Structure
Product Details
| Purity | >98% |
| Melting Point | Tm = 121 °C – 123 °C |
| Appearance | Off-white to pale beige powder |
MSDS Documentation
3-Fluoro-4-morpholinoaniline MSDS Sheet
Literature and Reviews
- Synthesis and spectral characterization of Schiff base complexes of Cu(II), Co(II), Zn(II) and VO(IV) containing 4-(4-aminophenyl)morpholine derivatives: antimicrobial evaluation and anticancer studies, K. Dhahagani et al., Spectrochim. Acta A Mol. Biomol. Spectrosc., 117(3), 87-94(2014); DOI: 10.1016/j.saa.2013.07.101.
- Biofilm inhibition of linezolid-like Schiff bases: synthesis, biological activity, molecular docking and in silico ADME prediction, J. Sangshetti et al., Bioorg. Med. Chem., 25, 874-880(2015); DOI: 10.1016/j.bmcl.2014.12.063
- Electrochemical oxidation of 4-morpholinoaniline in nonaqueous solvents, R. Esmaili et al, J. Electrochem. Soc., 159(8), H680-H684(2012); DOI: 10.1149/2.014208jes.