4-Fluoro-2-methylphenol
CAS Number 452-72-2
Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers
Fluorinated phenol derivative
Used as a synthesis intermediate for APIs and functional polymers
Specifications | MSDS | Literature and Reviews
4-Fluoro-2-methylphenol (CAS number 452-72-2), also knowns as 4-fluoro-o-cresol, is a para-fluorinated o-cresol. 4-Fluoro-2-methylphenol commonly serves as a building block for active pharmaceutical ingredients (APIs). Compared to non-substituted phenol, 4-fluoro-2-methylphenol offers selective inhibition over receptor tyrosine kinase and improves hepatocyte stability in quinazolines.
A tetradentate aminophenol ligand can be prepared from 4-fluoro-2-methylphenol, ethanolamine and formaldehyde via thermal Mannich condensation. A ligand-to-metal charge transfer (LMCT) complex synthesised from the aminophenol ligand and vanadium, demonstrates a charge transfer state with a lifetime of 423 ps. The long-lived LMCT complex is ideal for driving photochemical reactions. Furthermore, 4-Fluoro-2-methylphenol can be grafted onto natural polymer such as fax and coconut fibres catalysed by laccase for the modification of hydrophobicity.
Multiple functional groups
For facile synthesis
Fluorinated phenol building block
For graft polymers, medicinal chemistry and biochemistry research
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
| CAS Number | 452-72-2 |
| Chemical Formula | C7H7FO |
| Full Name | 4-Fluoro-2-methylphenol |
| Molecular Weight | 126.13 g/mol |
| Synonyms | 4-Fluoro-o-cresol |
| Classification / Family | Fluorinated building blocks, Phenol building blocks, APIs, Graft polymers, Photoresists |
Chemical Structure
Product Details
| Purity | 98% |
| Melting Point | Tm = 37 °C – 38 °C |
| Appearance | Pale yellow crystals |
MSDS Documentation
4-Fluoro-2-methylphenol MSDS Sheet
Literature and Reviews
- The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity, R. Newton et al., Eur. J. Med. Chem., 112, 20–32(2016); DOI: 10.1016/j.ejmech.2016.01.039.
- Fundamental understanding of chemical processes in extreme ultraviolet resist materials, O. Kostko et al., J. Chem. Phys., 149, 154305(2018); DOI: 10.1063/1.5046521.
- Long-lived LMCT in a d0 vanadium(V) complex by internal conversion to a state of 3dxy character, S. Choing et al., J. Phys. Chem. C, 119, 17029–17038(2015); DOI: 10.1021/acs.jpcc.5b00513.