4-Fluorobenzenesulfonamide
CAS Number 402-46-0
Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers
A fluorinated sulfonamide building block
Used as a synthesis intermediate for APIs and bioimaging fluorophores
Specifications | MSDS | Literature and Reviews
4-Fluorobenzenesulfonamide (CAS number 402-46-0) is a para-substituted fluorinated benzenesulfonamide. 4-Fluorobenzenesulfonamide consists of a sulfonyl group terminated by an amine, enabling functionalisation through nucleophilic substitution. For instance, 4-fluorobenzenesulfonamide reacts with benzaldehyde to form (E)-N-(4-fluorobenzylidene)-4-fluorobenzenesulfonamide as an antimicrobial. A potential anti-tumour drug bis(dithiocabinmato)-platinum(II) can be synthesised from 4-fluorobenzenesulfonamide with carbon disulfide and platinum complex. PI3K/mTOR dual inhibitors are designed and synthesised from 4-fluorobenzenesulfonamide, showing half maximal inhibitory concentration up to 2.88 ± 0.58 µM.
Other than pharmaceutical applications, 4-fluorobenzenesulfonamide has been exploited to functionalise rhodamines for systematic tuning of the equilibrium of spirocyclisation for high resolution bioimaging.
Multiple functional groups
For facile synthesis
Fluorinated sulfonamide building block
For drug discovery, medicinal chemistry and bioimaging research
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
| CAS Number | 402-46-0 |
| Chemical Formula | C6H6FNO2S |
| Full Name | 4-Fluorobenzenesulfonamide |
| Molecular Weight | 175.18 g/mol |
| Synonyms | p-Fluorobenzenesulfonamide, 4-Fluorobenzene-1-sulfonamide |
| Classification / Family | Fluorinated building block, Sulfonamides, APIs, Fluorophores |
Chemical Structure
Product Details
| Purity | 98% |
| Melting Point | Tm = 124 °C – 127 °C |
| Appearance | White powder |
MSDS Documentation
4-Fluorobenzenesulfonamide MSDS Sheet
Literature and Reviews
- Systematic tuning of rhodamine spirocyclization for super-resolution microscopy, N. Lardon et al., J. Am. Chem. Soc., 143(36), 14592–14600(2021); DOI: 10.1021/jacs.1c05004.
- Syntheses, crystal structure and spectroscopic characterization of new platinum(II) dithiocarbimato complexes, R. Amim et al., Polyhedron, 27, 1891–1897(2008); DOI: 10.1016/j.poly.2008.02.030.
- Design, synthesis and biological evaluation of novel phenylsulfonylurea derivatives as PI3K/mTOR dual inhibitors, B. Zhao et al., Molecules, 23, 1553(2018); DOI: 10.3390/molecules23071553.