4-Fluororesorcinol
CAS Number 103068-41-3
Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers
A fluorinated resorcinol building block
Used as a synthesis intermediate for dyes, liquid crystals and APIs
Specifications | MSDS | Literature and Reviews
4-Fluororesorcinol (CAS number 103068-41-3) is a fluorinated resorcinol, a meta-substituted benzenediol. One of the key applications of 4-fluororesorcinol is to synthesise fluorinated fluoresceins. One synthetic route is 4-fluororesorcinol reacting with benzaldehyde derivatives and followed by an oxidation by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Another method includes a reaction of 4-fluororesorcinol with phthalic anhydride catalysed by zinc chloride or methanesulfonic acid. It is feasible to synthesise bent-core azo-benzene liquid crystal mesogens from 4-fluororesorcinol with a bending angle of 121.5°.
4-Fluororesorcinol can also chelate to the copper centre in oxy-tyrosinase causing inactivation of the tyrosinase.
Multiple functional groups
For facile synthesis
Fluorinated resorcinol building block
For the synthesis of dyes, liquid crystals and APIs
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
| CAS Number | 103068-41-3 |
| Chemical Formula | C6H5FO2 |
| Full Name | 4-Fluoro-1,3-dihydroxybenzene |
| Molecular Weight | 128.10 g/mol |
| Synonyms | 4-Fluoro-1,3-benzenediol |
| Classification / Family | Fluorinated building block, Dyes, APIs, Liquid crystals |
Chemical Structure
Product Details
| Purity | 98% |
| Melting Point | Tm = 96 °C – 100 °C |
| Appearance | Beige powder |
MSDS Documentation
4-Fluororesorcinol MSDS SheetLiterature and Reviews
- Efficient two-step synthesis of 9-aryl-6-hydroxy-3H-xanthen-3-one-fluorophores, J. Bacci et al., J. Org. Chem., 70(22), 9051–9053(2005); DOI: 10.1021/jo051243i.
- Dark conglomerate phases of azobenzene derived bent-core mesogens — relationships between the molecular structure and mirror symmetry breaking in soft matter, M. Alaasar et al., Soft Matter, 10, 7285(2014); DOI: 10.1039/c4sm01255k.
- Mechanistic studies of the inactivation of tyrosinase by resorcinol, M. Stratford et al., ioorg. Med. Chem., 21, 1166–1173(2013); DOI: 10.1016/j.bmc.2012.12.031.