5-Cyano-2-fluoropyridine
CAS Number 3939-12-6
Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers
A fluorinated pyridine building block
Used for the synthesis of APIs and diketopyrrolopyrrole dyes
Specifications | MSDS | Literature and Reviews
5-Cyano-2-fluoropyridine (CAS number 3939-12-6) is a pyridine derivative with a fluorine and a nitrile at 2- and 5-positions. An anti-cancer Ube2T inhibitor is synthesised from 5-cyano-2-fluoropyridine through a two-step reaction process. The synthesis begins with the reaction of 5-cyano-2-fluoropyridine and pyrrolidine via nucleophilic aromatic substitution, followed by Pinner reaction to yield the amidine moiety.
5-Cyano-2-fluoropyridine is also employed in the synthesis of pyridine substituted dikeopyrrolopyrroles (DPPs) using diisopropyl succinate. The resulting pyridine-DPPs have bathochromically shifted absorption and emission bands.
Multiple functional groups
For facile synthesis
Fluorinated nicotinonitrile building block
for drug discovery, bioimaging dyes and biochemistry research
Worldwide shipping
Quick and reliable shipping
High purity
>97% High purity
General Information
| CAS Number | 3939-12-6 |
| Chemical Formula | C6H3FN2 |
| Full Name | 5-Cyano-2-fluoropyridine |
| Molecular Weight | 122.10 g/mol |
| Synonyms | 6-Fluoronicotinonitrile, 6-fluoropyridine-3-carbonitrile |
| Classification / Family | Fluorinated building blocks, Heterocyclic building blocks, APIs, Dyes |
Chemical Structure
Product Details
| Purity | 97% |
| Melting Point | Tm = 51 °C – 52 °C |
| Appearance | White crystals |
MSDS Documentation
5-Cyano-2-fluoropyridine MSDS Sheet
Literature and Reviews
- Discovery of a highly potent and selective dual PROTAC degrader of CDK12 and CDK13, J. Yang et al., J. Med. Chem., 65, 11066–11083(2022); DOI: 10.1021/acs.jmedchem.2c00384.
- Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements, J. Med. Chem., 60, 8183–8191(2017); DOI: 10.1021/acs.jmedchem.7b01071.
- The impact of the interplay between steric and electronic effects on the synthesis and optical properties of diketopyrrolopyrroles bearing pyridine moieties, O. Vakuliuk et al., ChemPhotoChem, 1, 243–252(2017); DOI: 10.1002/cptc.201600047.