(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone

CAS Number 1287211-10-2

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers

(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone MSDS

(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone CAS 1287211-10-2

A fluorinated chiral heterocyclic building block

Used as a synthesis intermediate for active pharmaceutical ingredients (APIs) and polymer in lithium solid-state batteries

Specifications | MSDS | Literature and Reviews

(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone (CAS number 1287211-10-2), a derivative of the well known 2-pyrrolidinone, is a five-membered lactam (γ-lactam) with a trifluoromethyl substituent on a S-chiral carbon centre (left-handed). Many derivatives of 2-pyrrolidinone are bioactive including cotinine (antidepressant), doxapram (respirator stimulant) and seletracetam (anticonvulsant). (5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone has a high potential for using in APIs development, due to the lipophilicity from trifluoromethyl group. The chiral centre is also preferred for systematic studies in medicinal chemistry.

Polyvinylpyrrolidone (PVP) is popularly used in development of solid-state batteries, as a binder maintaining cohesion for intercalation type cathodes. PVP is easily prepared through a radical polymerisation, while its monomer vinylpyrrolidone can be obtained from pyrrolidinone and acetylene.

Multiple functional groups

For facile synthesis

Worldwide shipping

Quick and reliable shipping

Fluorinated chiral pyrrolidone building block

For drug discoveries, organic synthesis, and batteries

High purity

>97% High purity

General Information

CAS Number	1287211-10-2
Chemical Formula	C₅H₆F₃NO
Full Name	(5S)-5-(Trifluoromethyl)pyrrolidin-2-one
Molecular Weight	153.10 g/mol
Synonyms	N/A
Classification / Family	Pyrrolidinone derivatives, Heterocyclic building block, Fluorinated building block, API synthesis intermediates, Batteries

Chemical Structure

Product Details

Purity	>97%
Boiling Point	T_m = 98 °C – 105 °C
Appearance	White powder/crystal

MSDS Documentation

(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone MSDS Sheet

Literature and Reviews

An overview on chemistry and biologcal importance of pyrrolidinone, Z. Hosseinzadeh et al., Curr. Org. Chem., 14, 1-13(2017);DOI: 10.2174/1570179414666170908165445.
Inks for Li-ion battery anodes printed by rotogravure, J. Mateo et al., Advances in Printing and Media Technology, 47(8), 171-176(2022); DOI: 10.14622/Advances_48_2022_04
PVP-assisted synthesis of ultrafine transition metal oxides encapsulated in nitrogen-doped carbon nanofibers as robust and flexible anodes for sodium-ion batteries, Q. Zhao et al, Carbon, 174, 325-334(2021); DOI:10.1016/j.carbon.2020.12.016.

PVP-derived carbon nanofibers harvesting enhanced anode performance for lithium ion batteries, L. Dong et al., RSC Adv., 6, 4193-4199(2016); DOI: 10.1039/C5RA23924A.
The role of polymers in lithium solid-state batteries with inorganic solid electrolytes, S. Senet al., J. Mater. Chem. A, 9, 18701–18732(2021); DOI: 10.1039/d1ta02796d.