6-Chloro-8-fluoroquinoline

CAS Number 52200-53-0

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers

6-Chloro-8-fluoroquinoline CAS 52200-53-0

A fluorinated heterocyclic building block

Used as a synthesis intermediate for APIs, DSSCs and sensors

Specifications | MSDS | Literature and Reviews

6-Chloro-8-fluoroquinoline (CAS number 52200-53-0) is a fluorinated quinoline derivative with a chlorine and a fluorine at 6- and 8-position respectively. This building block is best known for its used in active pharmaceutical ingredients (APIs), such as Besifloxacin and Clinafloxacin in topical antibiotic treatments and conjunctive bacterial infections. Other than pharmaceutical uses, 6-Chloro-8-fluoroquinoline is a synthesis intermediate for Schiff bases, through nucleophilic aromatic substitution. These Schiff bases are used for metal-ion recognition sensors because their fluorescent emissions shift after chelating to a metal centre.

Besifloxacin chemical structure — Besifloxacin, a fluoroquinolone antibiotic

The Schiff bases formed by this building block are typically bidentate/tridentate ligands which readily coordinate to Ru and Ir ion centres to form dye complexes in applications of dye-sensitized solar cells(DSSCs).

Multiple functional groups

For facile synthesis

Worldwide shipping

Quick and reliable shipping

Fluorinated quinoline building block

For drug discoveries, dyes, and solar cells

High purity

>98% High purity

General Information

CAS Number	52200-53-0
Chemical Formula	C₉H₅ClFN
Full Name	6-Chloro-8-fluoroquinoline
Molecular Weight	181.59 g/mol
Synonyms	N/A
Classification / Family	Fluorinated building block, Heterocyclic building block, Quinoline derivatives, Schiff base, Dyes, Semiconductor synthesis intermediates, organic photovoltaics

Chemical Structure

Product Details

Purity	>98%
Melting Point	T_m = 79 °C – 81 °C
Appearance	White to yellow crystal

MSDS Documentation

6-Chloro-8-fluoroquinoline MSDS Sheet

Literature and Reviews

Besifloxacin ophthalmic suspension 0.6% in the treatment of bacterial conjunctivitis patients with Pseudomonas aeruginosa infections, B. Silverstein et al., Clin. Ophthalmol., 6, 1987-1996(2012); DOI: 10.2147/OPTH.S35715.
Clinafloxacin for the treatment of bacterial endocarditis, D. Levine et al., Clin. Infect. Dis., 38(5), 620-631(2004); DOI: 10.1086/381670.
Copper(II) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer activity, Med. Chem. Commun., 9, 1663–1672(2018); DOI: 10.1039/c8md00223a.

A fluorescent sensor based on binaphthol-quinoline Schiff base for relay recognition of Zn²⁺ and oxalate in aqueous media, L. Tang et al., J. Chem. Sci., 128(8), 1337-1343(2016); DOI: 10.1007/s12039-016-1124-y.
Enhanced in vivo wound healing efficacy of a novel hydrogel loaded with copper(II) Schiff base quinoline complex(CuSQ) solid lipid nanoparticles, D. Abou El-ezz et al., Pharmaceuticals, 15(8), 978(2022); DOI: 10.3390/ph15080978.
Nano-synthesis, characterization and spectroscopic studies of chromium (III) complex derived from new quinoline-2-one for solar cell fabrication, A. Salman., J. Phys.: Conf. Ser., 1853, 012021(2021); DOI: 10.1088/1742-6596/1853/1/012021/
Ruthenium-triphenylphosphine complex with pendent quinolyl Schiff base ligand: synthesis, spectral characterization and catalytic property, S. Kundu et al., J. Indian Chem. Soc., 92, 1847-1853(2015); DOI: 10.5281/zenodo.5599621.
Theoretical and experimental investigations of large stokes shift fluorophores based on a quinoline scaffold, B. Czaplińska et al., Molecules, 25, 2488(2020); DOI: 10.3390/molecules25112488.