6-Fluoro-4-chromanone
CAS Number 66892-34-0
Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers
A fluorinated heterocyclic building block
Used as a synthesis intermediate for enzyme inhibitors and dye-sensitized solar cells (DSSCs)
Specifications | MSDS | Literature and Reviews
6-Fluoro-4-chromanone (CAS number 66892-34-0) is a fluorinated heterocyclic compound that is a benzene-fused dihydropyran with a fluorine and a ketone substituent. The fluorine group enhances the lipophilicity of 6-fluoro-4-chromanone, and also favours further functionalization via nucleophilic aromatic substitution. Through this method, chromophoric xerogels are synthesized for sensor applications. The ketone substituent supports functionalization through an aldol reaction. 6-Fluoro-4-chromanone is also used as an enzyme inhibitor such as Sirtuin 2 (an enzyme related to aging diseases).
6-Fluoro-4-chromanone can be fully aromatized in an oxidation reaction catalysed by iodine, to expand its application to DSSCs.
Multiple functional groups
For facile synthesis
Worldwide shipping
Quick and reliable shipping
High purity
>99% High purity
Fluorinated chromanone building block
For semiconductors, dyes, and solar cells
General Information
| CAS Number | 66892-34-0 |
| Chemical Formula | C9H7FO2 |
| Full Name | 6-Fluoro-2,3-dihydro-4H-chromen-4-one |
| Molecular Weight | 166.15 g/mol |
| Synonyms | 6-Fluorochroman-4-one |
| Classification / Family | Dyes, Semiconductor synthesis intermediates, organic photovoltaics |
Chemical Structure
Product Details
| Purity | 99% |
| Boiling Point | Tm = 114 °C – 116 °C |
| Appearance | Off-white powder |
MSDS Documentation
6-Fluoro-4-chromanone MSDS Sheet
Literature and Reviews
- A one-pot synthesis of chromophoric silicate-based xerogels, S. Spange et al., Angew. Chem. Int. Ed., 41, 1729-1732(2002); DOI: 10.1002/1521-3773(20020517)41:10<1729::AID-ANIE1729>3.0.CO;2-V.
- Efficient synthesis of chromones with alkenyl functionalities by the Heck reaction, T. Patonay et al., Aust. J. Chem., 63, 1582–1593(2010); DOI:10.1071/CH10295.
- Eploration of chromone-based thiosemicarbazone derivatives: SC-XRD/DFT, spectral (IR, UV−Vis) characterization, and quantum chemical analysis, R. Basri et al., ACS Omega, 5, 30176-30188(2020); DOI: 10.1021/acsomega.0c04653.