6-Fluoronicotinic acid

CAS Number 403-45-2

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers

A fluorinated nicotinic acid building block

Used as a bioactive molecule for medicinal chemistry research

Specifications | MSDS | Literature and Reviews

6-Fluoronicotinic acid (CAS number 403-45-2), also recognized as niacin, is a fluorinated nicotinic acid. 6-Fluoronicotinic acid is a derivative of pyridine, with a carboxylic acid at 3-position and a fluorine at 6-position. Nicotinic acid is an important food supplement and used to treat pellagra, a vitamin B₃ deficiency disease. 6-Fluoronicotinic acid is applied as a molecular scaffold to synthesize tracers for positron emission tomography, for visualizing and measuring changes in metabolic processes.

Being bioactive, 6-fluoronicotinic acid is commonly used as a building block for active pharmaceutical ingredients (APIs). A derivative of quinoline-8-yl-nicotinamide synthesised from 6-fluoronicotinic acid is investigated for pancreatic cancer treatment.

Multiple functional groups

For facile synthesis

Fluorinated carboxylic acid building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	403-45-2
Chemical Formula	C₆H₄FNO₂
Full Name	2-Fluoro-5-pyridinecarboxylic acid
Molecular Weight	141.10 g/mol
Synonyms	6-Fluoropyridine-3-carboxylic acid
Classification / Family	Fluorinated building blocks, Heterocyclic building blocks, APIs, Ligands

Chemical Structure

Product Details

Purity	98%
Melting Point	T_m = 144 – 148°C
Appearance	White powder

MSDS Documentation

6-Fluoronicotinic acid MSDS Sheet

Literature and Reviews

Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [18F]ICF01006, a highly promising melanoma PET tracer, L. Rbah-Vidal et al., Eur. J. Nucl. Med. Mol. Imaging, 39, 1449–1461(2012); DOI: 10.1007/s00259-012-2168-y.
Fast indirect fluorine-18 labelling of protein/peptide using the useful 6-fluoronicotinic acid-2,3,5,6-tetrafluorophenyl prosthetic group: a method comparable to direct fluorination, F. Basuli et al., J. Labelled Comp. Radiopharm., 60(3), 168–175(2017); DOI: 10.1002/jlcr.3487.
Induction of genes implicated in stress response and autophagy by a novel quinolin-8-yl-nicotinamide QN532 in pancreatic cancer, Y. Kuang et al., J. Med. Chem., 65(8), 6133–6156(2022); DOI: 10.1021/acs.jmedchem.1c02207.

Structural and spectroscopic characteristics of Ni^II and Cu^II complexes with poly(vinyl alcohol-nicotinic acid) copolymers for photocatalytic degradation of indigo carmine dye, I. Ali et al., Crystals, 11, 1244(2021); DOI: 10.3390/cryst11101244.