1-Bromo-2-chloro-4-fluorobenzene
CAS Number 110407-59-5
Chemistry Building Blocks, Fluorinated Building Blocks, Materials, Monomers
A polyhalogenated benzene building block
Used as an intermediate for APIs synthesis in treatment of breast cancer and catalysts in peptide synthesis.
Specifications | MSDS | Literature and Reviews
1-Bromo-2-chloro-4-fluorobenzene (CAS number 110407-59-5) is derived from benzene, bearing bromide, chloride and fluoride substituents. 1-Bromo-2-chloro-4-fluorobenzene serves as a crucial building block for synthesising brilanestrant, a selective estrogen receptor degrader used in the treatment of breast cancer. 1-Bromo-2-chloro-4-fluorobenzene controls the potency on the degradation of estrogen receptor 1 (ERα), demonstrating an effective concentration of 0.7 nM.
1-Bromo-2-chloro-4-fluorobenzene is also used in the preparation of a biphenyl catalyst for peptide synthesis. The preparation of the catalyst begins with the synthesis of the Grignard reagent of 1-bromo-2-chloro-4-fluorobenzene yielding a magnesium bromide analogue. The resulting product subsequently reacts with trimethyl borate, followed by an acid hydration. The boronic acid product shows high catalytic efficiency of peptide synthesis, achieving a 97% conversion over a 4-hour reaction.
Multiple functional groups
For facile synthesis
Fluorinated benzene building block
for drug discovery, medicinal chemistry and biochemistry research
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
| CAS Number | 110407-59-5 |
| Chemical Formula | C6H3BrClF |
| Full Name | 1-Bromo-2-chloro-4-fluorobenzene |
| Molecular Weight | 209.44 g/mol |
| Synonyms | 2-Chloro-4-fluorobromobenzene |
| Classification / Family | Fluorinated building blocks, Brominated building blocks, Chlorinated building blocks, APIs, Catalysts |
Chemical Structure
Product Details
| Purity | 98% |
| Boiling Point | Tb = 193 °C – 195 °C at 760 mmHg |
| Relative Density | 1.75 g/mL |
| Appearance | Clear liquid |
MSDS Documentation
1-Bromo-2-chloro-4-fluorobenzene MSDS Sheet
Literature and Reviews
- Fluoronaphthalene building blocks via arynes: a solution to the problem of positional selectivity, E. Masson et al., Eur. J. Org. Chem., 2005(20), 4401–4405(2005); DOI: 10.1002/ejoc.200500390.
- Synthesis of mono- and dimethoxylated polychlorinated biphenyls derivatives starting from fluoroarene derivatives, R. Dhakal et al., Environ. Sci. Pollut. Res. Int., 27(9), 8905–8925(2020). DOI: 10.1007/s11356-019-07133-3.
- Borinic acid catalysed peptide synthesis, T. El Dine et al., Chem. Commun., 51, 16084–16087(2015); DOI: 10.1039/c5cc06177f.