6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

CAS Number 84163-13-3

Chemistry Building Blocks, Fluorinated Building Blocks, Heterocyclic Building Blocks, Materials, Monomers

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride MSDS

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride CAS 84163-13-3

A fluorinated heterocyclic building block

A synthesis intermediate and molecular scaffold for medicinal chemistry research and drug discovery

Specifications | MSDS | Literature and Reviews

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride (CAS number 84163-13-3), a fluorinated heterocycle compound, contains a benzisoxazole (a benzene-fused isoxazole), a piperidine and a fluorine substituent. 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride is primarily involved in the synthesis of atypical antipsychotics such as risperidone, paliperidone and iloperidone for the treatment of schizophrenia. 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride is also exploited as a molecular scaffold for antimicrobials, antidepressants and anticancer drugs.

resperidone — Chemical structure of risperidone, an antipsychotic for treating schizophrenia and bipolar disorder

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride can be easily modified via acylation and sulfonylation with acyl chloride or sulfonyl chloride. It also reacts with alkyl chloride/bromide to form N-alkylated products.

Multiple functional groups

For facile synthesis

Fluorinated piperidylbenzisoxazole building block

For drug discovery, medicinal chemistry, and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information

CAS Number	84163-13-3
Chemical Formula	C₁₂H₁₄ClFN₂O
Full Name	6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
Molecular Weight	256.70 g/mol
Synonyms	R-56109 hydrochloride, 4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride, 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Classification / Family	Fluorinated building blocks, Heterocyclic building blocks, APIs, Drug discovery

Chemical Structure

Product Details

Purity	98%
Melting Point	N/A
Appearance	White powder

MSDS Documentation

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride MSDS Sheet

Literature and Reviews

An improved and efficient process for the production of highly pure paliperidonem, a psychotropic angent, via DBU catalyzed N-alkylation, P. Solanki et al., ACS Sustainable Chem. Eng., 1(2), 243–248(2013); DOI: 10.1021/sc3000916.
In silico docking studies and synthesis of new phosphoramidate derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole as potential antimicrobial agents, M. Sivala et al., J. Recept. Signal Transduct., 40(5), 486–492(2020); DOI: 10.1080/10799893.2020.1752719.
Solution phase synthesis of a diverse library of benzisoxazoles utilizing the [3+2] cycloaddition of in situ generated nitrile oxidies and arynes, A. Dubrovskiy et al., ACS Comb Sci., 15(4), 193–201(2013); DOI: 10.1021/co300159g.

Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with 6-fluoro-3-(4-piperidynyl)-1,2-benzisoxazole moiety as potential SSRI and 5-HT_1A receptor ligands, M. Król et al., Int. J. Mol. Sci., 22, 2329(2021); DOI: 10.3390/ijms22052329
Synthesis of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives as antiproliferative agents: a structure–activity relationship study, S. Prasad et al., Investigational New Drugs, 27, 534–542(2009); DOI: 10.1007/s10637-008-9205-5.