Fluorinated Building Blocks

Containing fluorine to replace halogenated atoms, such as hydrogen, fluorinated building blocks form carbon-fluoride bonds or provide negatively charged fluorine.

Within our extensive range of fluorinated building blocks, you will find mono-, double-, or triple-hydrogen replaced polymers for a variety of applications.

Features and Applications

These compounds are desirable because fluorine has high electronegativity, a small atomic radius, and high polarizability, plus unique chemical, physical and biomedical properties.
With great electron-withdrawn ability and minimal steric perturbation, fluorinated building blocks are widely used for the synthesis of drugs such as anti‐inflammatory and anticancer agents.
Agrochemicals that contain fluorine in their chemical structures show dramatic effect on the biological activity of herbicides, insecticides, fungicides, and plant growth.

Browse Fluorinated Building Blocks

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Potassium nonafluoro-1-butanesulfonate

CAS 29420-49-3

From $65

2-Fluorobiphenyl

CAS 321-60-8

From $52

Pentafluorobenzoic acid

CAS 602-94-8

From $39

2,4,5-Trifluorophenylacetic acid

CAS 209995-38-0

From $52

4-Fluoro-1,2-phenylenediamine

CAS 367-31-7

From $46

5-Fluorobenzoxazole-2-thiol

CAS 13451-78-0

From $59

5-Bromo-3-fluoropyridine-2-carboxylic acid

CAS 669066-91-5

From $72

7-Fluoro-4-hydroxycoumarin

CAS 2145-27-9

From $65

2-Amino-5-chloro-3-fluoropyridine

CAS 246847-98-3

From $52

5-Fluoro-2-methylbenzoic acid

CAS 33184-16-6

From $59

5-Bromo-4-fluoro-2-methylaniline

CAS 627871-16-3

From $78

3′-Bromo-4′-fluoroacetophenone

CAS 1007-15-4

From $46

3-Fluoro-5-(trifluoromethyl)benzoic acid

CAS 161622-05-5

From $39

5-Chloro-2-fluorobenzonitrile

CAS 57381-34-7

From $52

2-Fluoro-6-methylbenzoic acid

CAS 90259-27-1

From $43

4′-Fluoro-3′-nitroacetophenone

CAS 400-93-1

From $46

4-Fluoro-3-methylbenzoic acid

CAS 403-15-6

From $65

1,3,5-Tris(3-fluoro-4-formylphenyl)benzene

CAS 2088007-04-7

$104
From $52

5-Chloro-2-fluorobenzoic acid

CAS 394-30-9

From $65

2-Fluoro-5-methylbenzoic acid

CAS 321-12-0

From $65

trans-3,4-Difluorocinnamic acid

CAS 112897-97-9

From $65

4-Fluoro-2-iodobenzoic acid

CAS 56096-89-0

From $46

3-Fluoro-4-iodopyridine

CAS 22282-75-3

From $65

2-Chloro-5-fluoronitrobenzene

CAS 345-17-5

From $59

4-Bromo-3-fluorobenzonitrile

CAS 133059-44-6

From $65

3-Bromo-5-fluorophenol

CAS 433939-27-6

From $43

4-Bromo-3-fluoroiodobenzene

CAS 136434-77-0

From $46

5-Difluoromethoxy-2-mercaptobenzimidazole

CAS 97963-62-7

From $85

6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline

CAS 31009-34-4

From $124

4-Bromo-6-fluoroquinoline

CAS 661463-17-8

From $124

4-Amino-2-(trifluoromethyl)pyridine

CAS 147149-98-2

From $65

1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde

CAS 936940-82-8

From $91

Methyl 6-fluoropyridine-2-carboxylate

CAS 455-71-0

From $111

4-Hydroxy-2-(trifluoromethyl)benzoic acid

CAS 320-32-1

From $85

5-Bromo-2-fluoropyrimidine

CAS 62802-38-4

From $78

3-Chloro-5-fluoroaniline

CAS 4863-91-6

From $85

6-Fluoropyridine-2-carbonitrile

CAS 3939-15-9

From $104

4-Fluoro-4′-methoxybenzophenone

CAS 345-89-1

From $117

2,4,6-Trifluorophenylacetic acid

CAS 209991-63-9

From $117

2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid

CAS 652-34-6

From $104

2-Fluoropyridine-3-carbonitrile

CAS 3939-13-7

From $117

2-Bromo-5-fluorobenzonitrile

CAS 57381-39-2

From $78

1-Bromo-2-chloro-4-fluorobenzene

CAS 110407-59-5

From $91

2-Fluoro-4-(trifluoromethyl)benzoic acid

CAS 115029-24-8

From $130

3-Fluoro-4-methoxybenzoic acid

CAS 403-20-3

From $117

4-Methoxy-3-(trifluoromethyl)aniline

CAS 393-15-7

From $117

4-Fluoro-2-methylbenzonitrile

CAS 147754-12-9

From $117

3-Fluoro-4-(trifluoromethyl)benzoic acid

CAS 115754-21-7

From $117

3,5-Difluoropyridine-2-carbonitrile

CAS 298709-29-2

From $117

5-Cyano-2-fluoropyridine

CAS 3939-12-6

From $117

2,6-Difluorocinnamic aldehyde

CAS 117338-43-9

From $117

2-Fluoro-4-hydroxybenzoic acid

CAS 65145-13-3

From $117

3-Chloro-2-fluorobenzoic acid

CAS 161957-55-7

From $98

2-Fluoro-3-methoxybenzaldehyde

CAS 103438-88-6

From $179

3-Fluorobenzoic hydrazide

CAS 499-55-8

From $130

2-Amino-5-fluorobenzonitrile

CAS 61272-77-3

From $104

4-Fluoro-2-methylphenol

CAS 452-72-2

From $78

2,4,5-Trifluorobenzonitrile

CAS 98349-22-5

From $104

4-Chloro-3-fluoroaniline

CAS 367-22-6

From $65

2-Fluoro-4-nitroaniline

CAS 369-35-7

From $91

3-Fluoro-2-methylbenzoic acid

CAS 699-90-1

From $117

2-Amino-6-fluorobenzonitrile

CAS 77326-36-4

From $117

3-Fluoro-p-anisidine

CAS 366-99-4

From $117

3′-Fluoro-4′-methoxyacetophenone

CAS 455-91-4

Price $117

2-Bromo-4-fluorobenzonitrile

CAS 36282-26-5

From $104

3-Fluoro-2-pyridinecarbonitrile

CAS 97509-75-6

From $91

2-Amino-3-fluoropyridine

CAS 21717-95-3

From $104

3-Fluoro-4-hydroxybenzaldehyde

CAS 405-05-0

From $104

α,α-Difluorophenylacetic acid

CAS 360-03-2

From $91

3,3-Difluoropiperidine hydrochloride

CAS 496807-97-7

From $78

2,2-Difluorocyclopropanecarboxylic acid

CAS 107873-03-0

From $117

4-Fluoro-β-nitrostyrene

CAS 706-08-1

From $117

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

CAS 82671-02-1

From $117

2-Fluoro-4-(trifluoromethyl)aniline

CAS 69409-98-9

From $117

N-Boc-4,4-difluoro-L-proline

CAS 203866-15-3

From $91

3,4,5-Trifluorobenzoic acid

CAS 121602-93-5

From $117

2-Bromo-3′-fluoroacetophenone

CAS 53631-18-8

From $151

4-Fluororesorcinol

CAS 103068-41-3

From $91

3,4,5-Trifluoroaniline

CAS 163733-96-8

From $72

4-Fluorobenzenesulfonamide

CAS 402-46-0

From $85

2-Fluoro-5-nitrobenzoic acid

CAS 7304-32-7

From $85

1-Bis(4-fluorophenyl)methyl piperazine

CAS 27469-60-9

From $104

3,5-Difluorobenzonitrile

CAS 64248-63-1

From $85

6-Fluoronicotinic acid

CAS 403-45-2

From $99

2-Bromo-4-fluoropyridine

CAS 357927-50-5

From $163

3-Fluoro-2-hydroxybenzaldehyde

CAS 394-50-3

From $143

2-Chloro-5-fluoropyrimidine

CAS 62802-42-0

From $130

2-Bromo-6-fluorobenzaldehyde

CAS 360575-28-6

From $130

2-Fluoro-5-nitrobenzonitrile

CAS 17417-09-3

From $94

Bis(4-fluorophenyl)methanol

CAS 365-24-2

From $137

N-Boc-trans-4-fluoro-L-proline

CAS 203866-14-2

From $99

(S)-(+)-3-Fluoropyrrolidine hydrochloride

CAS 136725-53-6

From $104

Methyl pentafluorobenzoate

CAS 36629-42-2

From $99

5-Fluorosalicylic acid

CAS 345-16-4

From $143

(R)-(−)-3-Fluoropyrrolidine hydrochloride

CAS 136725-55-8

From $94

4-Bromo-2,6-difluoroaniline

CAS 67567-26-4

From $99

2-Fluoroadenine

CAS 700-49-2

From $117

3,3-Difluoropyrrolidine hydrochloride

CAS 163457-23-6

From $143

4-Fluoro-3-nitrobenzoic acid

CAS 453-71-4

From $86

2-Amino-4-fluorophenol

CAS 399-97-3

From $73

2,4-Difluorobenzonitrile

CAS 3939-09-1

From $86

2,4-Difluoro-(1H-1,2,4-triazolyl)acetophenone

CAS 86404-63-9

From $130

4,4′-Bis(trifluoromethyl)-2,2′-bipyridine

CAS 142946-79-0

From $130

5-Bromo-2-fluoropyridine

CAS 766-11-0

From $137

1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone

CAS 211108-50-8

From $117

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

CAS 84163-13-3

From $104

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

CAS 100361-18-0

From $150

3-Fluoro-4-morpholinoaniline

CAS 93246-53-8

From $130

Benzyl (3-Fluoro-4-morpholinophenyl)carbamate

CAS 168828-81-7

From $130

5-Fluoroisatin

CAS 443-69-6

From $99

5-Fluorooxindole

CAS 56341-41-4

From $260

5-(Trifluoromethoxy)isatin

CAS 169037-23-4

From $150

6-Fluoroindole-2-carboxylic acid

CAS 3093-97-8

From $137

6-Fluoroindole

CAS 399-51-9

From $104

5-Fluoroindole

CAS 399-52-0

From $130

7-Fluoroindole

CAS 387-44-0

From $221

3-(4-Fluorophenyl)-1-isopropylindole

CAS 93957-49-4

From $130

4-Fluoroindole

CAS 387-43-9

From $130

4-(Trifluoromethyl)-1H-imidazole

CAS 3468-69-8

From $215

1-[2-(Trifluoromethyl)phenyl]imidazole

CAS 25371-96-4

From $228

3-(Trifluoromethyl)-2-pyridone

CAS 22245-83-6

From $130

5-(Trifluoromethyl)-2-pyridone

CAS 33252-63-0

From $130

2-(Trifluoromethyl)thioxanthen-9-one

CAS 1693-28-3

Price $124

2-Furoyltrifluoroacetone

CAS 326-90-9

From $130

7-(Diethylamino)-4-(trifluoromethyl)coumarin

CAS 41934-47-8

From $143

7-Hydroxy-4-(trifluoromethyl)coumarin

CAS 575-03-1

From $73

2-Fluoro-9H-carbazole

CAS 391-53-7

From $176

AB-TFMB

CAS 1449757-11-2

From $117

PTFE

The benchmark compound, polytetrafluoroethylene (PTFE), is industrially referred to as Teflon. PTFE is hyper-hydrophobic as fluorine replaces all four hydrogens across the repeating structure. While being inert to most chemicals, including acids and bases, PTFE has excellent electrical insulation and dielectric strength.

Anaesthetics

Compared to non-fluorinated anaesthetics, fluorinated anaesthetics are longer-lasting and almost insoluble in blood. It is estimated that over 20% of marketed drugs are fluoro-pharmaceuticals.

Fluorinated Building Blocks

Features and Applications

Browse Fluorinated Building Blocks

More on Fluorinated Building Blocks

PTFE

Anaesthetics